Author
Vanderbilt UniversityORCID 0009-0000-9594-0457Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Siddharth Nimkar, Thu Nguyen, Deepti Karandur…·John Kuriyan
The paper identifies and redesigns energetically frustrated regions in a defective T4 clamp loader to restore function through conformational balance and stability.
Subu Subramanian, Weilin Zhang, Siddharth Nimkar…·John Kuriyan
The paper shows that single point mutations can restore function to a defective DNA polymerase clamp-loader complex by compensating for reduced affinity between the clamp loader and the sliding clamp.
Siddharth Nimkar, Baskaran Anand
This study shows that Cas3/I-C cleaves target DNA independently of Cascade composition, revealing conserved mechanisms across type I-C and I-E CRISPR systems.