Tsung Wai Kan

This paper shows HBx promotes hepatocyte survival and reduces differentiation in human liver organoids, potentially contributing to liver cancer.

The paper identifies CHEK1 and BIRC5 as therapeutic targets in ARID1A-deficient bladder cancer using patient-derived tumoroids and public datasets.

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

This study identifies PCID2 as a novel HIV-1 latency-promoting factor that represses transcription and dysregulates viral RNA processing through its role in the TREX2 complex.

Catchet-MS identifies thalidomide analogues targeting IKZF1 as novel HIV-1 latency reversal agents by reversing latency in CD4+ T-cells.

This study identifies 10 novel host factors involved in HIV latency using a haploid genetic screen and validates their roles through functional assays and drug testing.

The paper shows ATP hydrolysis enables chromatin remodeler release, allowing continuous genome probing by limiting BRM chromatin binding.

The paper identifies gliotoxin as a novel LRA that disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency in CD4+ T cells.