Laura E. Kuil

This study investigates how loss of the enteric nervous system in zebrafish affects intestinal cell composition and identifies similar changes in human HSCR tissues.

This study evaluates the efficacy of the MPS1 inhibitor NTRC 0066-0 against glioblastoma in vitro and in vivo, finding strong in vitro activity but no antitumor effect in mouse models.

This study investigates how CSF1R inhibition during cranial radiotherapy affects the brain's immune environment and glial dynamics, showing sustained microglial loss and monocyte replacement.

This study shows that high-dose CSF1R inhibitors pexidartinib and sotuletinib rapidly deplete microglia despite limited brain penetration, with significant off-target effects on other immune and tissue cells.

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

The paper performs single-cell RNA sequencing on larval zebrafish ENS to identify previously uncharacterized neuronal and glial populations and reveals a binary neurogenic branching mechanism.

The paper identifies large copy number losses as contributors to Hirschsprung disease, specifically in HSCR-AAM patients, and validates four genes involved in enteric nervous system development.

The paper studies macrophage development in zebrafish lacking CSF1R, finding developmental arrest and the emergence of Csf1r-independent metaphocytes.

The paper uses a CRISPR/Cas9 screen in zebrafish to identify Il34 as a factor facilitating yolk sac macrophage distribution and brain colonization.