Aina Martí-Aranda

This study quantifies how domain extensions in a PDZ protein reshape its energy and allosteric landscapes through extensive mutational analysis.

The paper constructs allosteric maps for five human proteins to study how allostery evolves, finding conserved core interactions and protein-specific extensions.

This study shows that the genetic architecture of some proteins is simple, allowing accurate prediction using interpretable biophysical models despite the complexity of deep neural networks.