Sally O. Oswald

This study shows that phosphorylation at S345 converts HIF-2α from a transcription factor to an RNA-binding protein, altering its function in hypoxia response.

The paper identifies zDHHC23 as a hypoxia-responsive gene associated with metastasis in non-MYCN amplified neuroblastoma, suggesting it as a potential biomarker and therapeutic target.

This study identifies IL-1 and IL-6 as key drivers of neuroinflammation in HSV encephalitis, showing they are not reduced by corticosteroids and are associated with poor outcomes.

This study presents an optimized phosphoproteomics workflow using SP3 beads with improved phosphopeptide identification and detection of multiply phosphorylated peptides in HEK-293T cells.

The paper identifies sulfotyrosine (sY) sites in the human phosphoproteome by distinguishing them from phosphorylation using mass error shifts and filters out false positives, finding 31 convincing sY sites.

This study investigates how redox regulation via cysteine oxidation controls BRSK1/2 kinase activity, revealing conserved mechanisms that modulate catalytic function through disulfide bond formation and salt bridge disruption.