Louis T.A. Rolle

This study shows cancer cells survive genotoxic chemotherapy by entering a drug-tolerant persister state involving mitotic bypass and endocycling, which can be targeted by inhibiting WEE1 or Myt1.

This study shows that cancer cells surviving cisplatin chemotherapy increase OMA1 activity and mitochondrial fragmentation to resist oxidative stress.

The paper shows chemoresistant cancer cells are vulnerable to ferroptosis due to iron dysregulation, despite varying ferroptosis sensitivity in untreated cells.

This study shows that polyaneuploid cancer cells (PACCs) are pro-metastatic in vivo, based on in vitro and in vivo experiments in mouse models.

The paper introduces a flow cytometry method to detect and analyze rare CTCs and DTCs in cancer metastasis models, enabling the study of metastatic barriers across multiple steps in a single model system.