Author

Lawrence Middleton

AstraZeneca (United Kingdom)ORCID 0009-0002-2789-7244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:whole-exome sequencing· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Dimitrios VitsiosiD· 3 shared Quanli WangiD· 3 shared Andrew Robert HarperiD· 2 shared Dirk S. PauliD· 2 shared Keren CarssiD· 2 shared Ryan S. DhindsaiD· 2 shared Slavé PetrovskiiD· 2 shared Abhishek NagiD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetic & Genomic Medicine

Dimitrios VitsiosORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintOct 10, 2023

Applying Machine Learning on UK Biobank biomarker data empowers case-control discovery yield

Manik Garg, Marcin Karpiński, Dorota Matelska…·Dimitrios Vitsios

The paper uses machine learning to identify undiagnosed cases in UK Biobank data, improving gene-disease associations and discovering novel relationships.

1 citation

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJul 28, 2023

Assessing the role of rare pathogenic variants in heart failure progression by exome sequencing in 8,089 patients

Olympe Chazara, Marie‐Pierre Dubé, Quanli Wang…·Keren Carss

This study identifies seven genes associated with heart failure progression using exome sequencing in 8,089 patients and prioritizes them for therapeutic target validation.

1 citation

humanwhole-exome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintDec 24, 2021

Assessing the contribution of rare-to-common protein-coding variants to circulating metabolic biomarker levels via 412,394 UK Biobank exome sequences

Abhishek Nag, Lawrence Middleton, Ryan S. Dhindsa…·Slavé Petrovski

The paper assesses the contribution of rare-to-common protein-coding variants to metabolic biomarker levels using UK Biobank exome sequences and identifies novel gene-biomarker relationships.

12 citations

humanwhole-exome sequencing

𝕏 PostBluesky