Author

Simon L. Holtbrügge

Ruhr University BochumORCID 0009-0002-4182-4367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Assay:multiome· 1 Assay:protein structure· 1

Frequent Co-Authors

Lars V. SchäferiD· 2 shared Abhishek Kalarikkal· 1 shared Arnulf RosspeintneriD· 1 shared Dominik Gendreizig· 1 shared Enrica BordignoniD· 1 shared Laura GalazzoiD· 1 shared Saumyak MukherjeeiD· 1 shared Svetlana KucheriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiophysics

Lars V. SchäferORCID

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2 papers

Recent·Most cited

BiophysicsThe Journal of Chemical PhysicsPeer-reviewedAug 8, 2025

Robust Estimation of Rotational Diffusion Tensors of Proteins from Molecular Dynamics Simulations

Simon L. Holtbrügge, Lars V. Schäfer

This paper develops a method to estimate rotational diffusion tensors of proteins from MD simulations and validates it using BD simulations, finding ubiquitin exhibits nearly semi-isotropic diffusion.

3 citations

multiomemechanistic / dynamical model

𝕏 PostBluesky

BiophysicsThe Journal of Physical Chemistry BPeer-reviewedJan 16, 2025

A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation

Dominik Gendreizig, Abhishek Kalarikkal, Simon L. Holtbrügge…·Enrica Bordignon

This study combines molecular dynamics simulations and EPR spectroscopy to measure rotational diffusion changes in γD-crystallin during liquid-liquid phase separation.

6 citations

protein structureelectronic health records

𝕏 PostBluesky