BioinformaticsbioRxivPreprint
SNMF: Integrated Learning of Mutational Signatures and Prediction of DNA Repair Deficiencies
Sander Goossens, Yasin I. Tepeli, Colm Seale, Joana P. Gonçalves
The paper introduces SNMF, a supervised method to learn mutational signatures and predict DNA repair deficiencies, achieving high accuracy in cell lines and predicting DDR status in tumors.
DOI 10.1101/2024.11.27.624656