Cancer BiologyCancer Research CommunicationsPeer-reviewed
SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy
Beiyuan Liang, Evan H. Zhang, Zhen Ye…·Jing J. Wang
This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.