Author

Spencer T. Shah

Broad InstituteORCID 0009-0002-9082-3969Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Spencer T. Shah1 paper · Rice University

Biology Disciplines

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Bioengineering· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Organism:human· 3 Research Focus:perturbation response prediction· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

John G. DoenchiD· 3 shared Laura M. DrepanosiD· 3 shared E L KaplaniD· 2 shared Ganna ReintiD· 2 shared Sarra MerzoukiD· 2 shared Smriti SrikanthiD· 2 shared Allison Uebele· 1 shared Audrey L GriffithiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenomics

John G. DoenchORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsCell GenomicsPeer-reviewedMar 25, 2026

Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design

Laura M. Drepanos, Smriti Srikanth, Eleanor G. Kaplan…·John G. Doench

The paper presents a guide selection strategy to optimize Cas9 CRISPR knockout library design by balancing on-target and off-target activity, resulting in an updated validated library for the human genome.

9 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky

BioengineeringbioRxivPreprintFeb 26, 2026

Optimized parameters for Cas9 CRISPR interference library design

Smriti Srikanth, Fengyi Zheng, Laura M. Drepanos…·John G. Doench

This study designs an optimized Cas9 CRISPRi library by improving on-target scoring and analyzing off-target effects using updated datasets and methods.

2 citations

humanCRISPR screen

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedOct 14, 2025

Activity-based selection for enhanced base editor mutational scanning

E L Kaplan, Ryan J. Steger, Spencer T. Shah…·John G. Doench

This paper introduces an activity-based selection method to improve base editing efficiency and precision in identifying functional mutations.

9 citations

humanCRISPR screen

𝕏 PostBluesky