Mariana Garcia Sanchez

This paper designs de novo integrated domains using AI tools to enable plant NLR receptors to recognize non-cognate pathogen effectors, demonstrating functional immune responses and structural fidelity.

Conditioning RFdiffusion on edge beta-strand pairing yields specific binders to polar targets, with in silico success above 9.2% versus 0.98% for hotspot-only conditioning.

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.