Paul Sean Tipay

This paper evaluates how different molecular weights of tyramine-modified hyaluronan affect the polarization of THP-1 and PBMCs-derived macrophages, showing LMW THA drives M1-like polarization while HMW THA induces a mixed profile.

This study shows that dense and aligned collagen matrices suppress T-cell activation via YAP signaling, suggesting ways to improve immunotherapy by modulating T-cell responses in such environments.

This study shows that stiffening the tumor microenvironment via collagen alignment and crosslinking promotes M2 macrophage polarization, enhances immune suppression, and supports cancer cell growth.