Sevgi Sarıca

This study uses sulfated hydrogels to show that ECM sulfation enhances tumor cell survival and reduces chemotherapeutic efficacy by modulating stress responses and drug efflux.

The paper introduces an ECM-guided patient stratification pipeline using multi-omic data in lung cancer to identify ECM-grades with distinct clinical and molecular features and predict ECM-dependent drug responses.

The paper shows that increased sulfation in tumor ECM promotes cancer stemness and invasiveness through FAK-PI3K-mTOR signaling and RTK activation.