Cell BiologybioRxivPreprint
Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies
Braden Pate, Anna Goldstein, Madeline Labott…·Kim Vanuytsel
This paper uses iPSC-derived erythroid cells to model genetic diversity in sickle cell disease and shows they reflect heterogeneous responses to HbF-inducing therapies like hydroxyurea.