Author

Alexandra N. Grumet

Rutgers Cancer InstituteORCID 0009-0003-8820-4680Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander J. ValvezaniD· 2 shared Aidan R. ColeiD· 1 shared Amandine AmalriciD· 1 shared Apoorva UbovejaiD· 1 shared Ariel D. Lerner· 1 shared Baixue YangiD· 1 shared Cassandra L. Happe· 1 shared Frank Scallo· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Alexander J. ValvezanORCID

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2 papers

Recent·Most cited

Cell BiologyEMBO ReportsPeer-reviewedJun 13, 2025

ATR promotes mTORC1 activity via de novo cholesterol synthesis

Naveen Kumar Tangudu, Alexandra N. Grumet, Richard S. Fang…·Katherine M. Aird

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

6 citations

humanexperimental assay

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Molecular BiologyCell ReportsPeer-reviewedJul 26, 2024

mTORC1 activity oscillates throughout the cell cycle promoting mitotic entry and differentially influencing autophagy induction

Jay N. Joshi, Ariel D. Lerner, Frank Scallo…·Alexander J. Valvezan

This study shows mTORC1 activity oscillates during the cell cycle, peaks in S and G2, and is lowest in mitosis and G1, with distinct regulatory mechanisms and functional consequences.

25 citations

statistical modelexperimental assay

𝕏 PostBluesky