This study identifies a catalytically inactive PKCα mutation that drives chordoid glioma by rewiring cellular interactions and impairing cell junction function.

DOI 10.1073/pnas.2524934123

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintMay 29, 2026

Monocytes promote intraepithelial infiltration of effector memory CD8+ T cells in regressing tumors

Anaïs Vermare, Annavera Ventura, Adrien Rouault…·Nadège Bercovici

The paper identifies monocyte interactions with CD8+ T cells during tumor regression, showing their role in promoting T-cell infiltration and anti-tumor immunity.

DOI 10.64898/2026.05.28.728475

mousescRNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 7, 2026

Preconceptional immunomodulation partially corrects pregnancy associated abnormalities induced by endometriosis in a mice model, with a normalization of transcriptional alteration observed in the developing fetal maternal interface at the single cell level.

Kheira Bouzid, Roxane Bartkowski, Alix SILVERT…·Ludivine Doridot

This study shows that preconceptional immunomodulation reduces pregnancy complications in a mouse model of endometriosis by partially reversing transcriptional changes in fetal-maternal interfaces.

DOI 10.64898/2026.01.02.695166

mousescRNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintDec 3, 2025

Spatial and Multiomic profiling of muscle regeneration dynamics in Duchenne Muscular Dystrophy

Laura Virtanen, Chiara D’Ercole, Lucile Saillard…·Lorenzo Giordani

This study identifies NOTCH3 and GLIS3 as contributors to regeneration impairment in Duchenne Muscular Dystrophy using spatial transcriptomics and multiomic profiling.

DOI 10.64898/2025.12.02.691824

mousehuman

𝕏 PostBluesky