Shinya Yamanaka

This study shows that partial reprogramming leads to different recovery outcomes in human fibroblasts, T cells, and endothelial cells, revealing lineage-specific tradeoffs between rejuvenation and recovery.

The paper introduces a temporal AI model, MaxToki, trained on extensive gene data to predict cell state changes across human aging and identifies age-modulating targets.

This study shows that eIF4G2 is essential for intestinal stem cell maintenance and differentiation by facilitating the translation of histone modifiers.