ImmunologyeLifePeer-reviewed
CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis
Liangliang Fu, Chenghu Yin, Qin Ping Zhao…·Haibin Xia
This study identifies CD81+ senescent fibroblasts as key drivers of inflammation in periodontitis through the C3/C3aR1 axis and shows that senolytics and metformin can reduce inflammation and bone loss.