Patrick C. McGuire

This study evaluates three cell preservation methods for scRNA-seq across multiple sites, showing concordant cell type results but platform-specific gene expression differences and better granulocyte retention with preservation methods.

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

The paper uses multiomic profiling of the caudate nucleus to identify gene expression and chromatin changes in AUD, linking them to risk genes through QTL analysis.