Author

Madelyn Frazier

Howard Hughes Medical InstituteORCID 0009-0005-5694-024XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Christine JacobsiD· 1 shared Isaac A. PaddyiD· 1 shared Joshua W. McCauslandiD· 1 shared Laura M. K. DassamaiD· 1 shared Mekedlawit T. SetegneiD· 1 shared O. Eidam· 1 shared Poulami ChatterjeeiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Christine JacobsORCID

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1 paper

Recent·Most cited

BiochemistryProtein SciencePeer-reviewedAug 19, 2026

A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesis

Isaac A. Paddy, Joshua W. McCausland, Madelyn Frazier…·Laura M. K. Dassama

This study identifies HMGR as a critical enzyme in B. burgdorferi's mevalonate pathway, revealing its cofactor promiscuity and evolutionary significance.

DOI 10.1002/pro.70766

bacteria (other)proteomics

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