Author

Nicole A. Lester

Broad InstituteORCID 0009-0006-4506-0260Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 3 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Carina ShiauiD· 3 shared Jennifer SuiD· 3 shared Jennifer Yon-Li WoiD· 3 shared Jimmy A. GuoiD· 3 shared Mari A. Mino-KenudsoniD· 3 shared Maria L. GanciiD· 3 shared Martin HembergiD· 3 shared Nicholas J CaldwelliD· 3 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Carina ShiauORCID

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3 papers

Recent·Most cited

Cancer BiologyClinical Cancer ResearchPeer-reviewedMar 18, 2026

Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors

Jeanna M. Qiu, Jae Won Cho, Phuong Trang Nguyen…·William L. Hwang

This study identifies distinct malignant cell states and myeloid glutamate signaling in aggressive pancreatic neuroendocrine tumors, linking them to poor clinical outcomes and therapeutic vulnerabilities.

1 citation

humanscRNA-seq

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Cancer BiologybioRxivPreprintAug 26, 2025

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

Peter L. Wang, Nicole A. Lester, Ella N. Perrault…·William L. Hwang

This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.

DOI 10.1101/2025.08.26.672505

humanbulk RNA-seq

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Cancer BiologyNature GeneticsPeer-reviewedSep 3, 2024

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

Carina Shiau, Jingyi Cao, Dennis H. Gong…·William L. Hwang

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

105 citationstop 1%

humanspatial transcriptomics

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