Cell BiologyThe Journal of Cell BiologyPeer-reviewed
Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance
Zengqi Zhao, Qiang Chen, Xiaojun Xiang…·Qinghui Ai
This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.
24 citations