Yingnan Lei

This study shows that increased BCL2L1 and ID1 gene dosage in human pluripotent stem cells drives competitive advantage and fate bias toward non-neural ectodermal and extraembryonic fates during differentiation.

This study shows that loss of chromosome 18q in hESCs impairs differentiation into retinal progenitor cells by disrupting TGFβ signaling and anteroposterior neuroectodermal fate commitment.

The paper investigates the cellular consequences of aneuploidy in human blastocysts, finding p53-mediated apoptosis and impaired lineage segregation.

This study shows that 1q gain in hESCs increases MDM4 expression, giving a growth advantage during differentiation by reducing DNA damage sensitivity and altering differentiation capacity.

This study tracks genetic changes in human pluripotent stem cells over time, finding that recurrent chromosomal gains drive the accumulation of other mutations.

This study shows that loss of chromosome 18q in human embryonic stem cells impairs neuroectoderm commitment and cardiac progenitor differentiation through SALL3 downregulation.