Jack E. Roettger

This study shows that gasdermin E is not essential for H1N1 influenza virus pathogenesis in mice, as Gsdme-/- mice exhibit similar infection outcomes to wild-type mice.

This study shows that activating AMPK in mice infected with a modified H1N1 virus reduces cardiac damage by restoring mitochondrial function and improving survival.

This study shows that IFITM3 deficiency accelerates SARS-CoV-2 adaptation in mice, revealing how variant traits influence tropism and pathogenesis across hosts.

This study shows that IFITM3 deficiency in mice allows avian influenza viruses to infect and adapt more effectively, suggesting a role for IFITM3 in preventing zoonotic virus emergence.