Author

Alexis N. Brumwell

University of California, San FranciscoORCID 0009-0006-8441-6354Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Harold A. ChapmaniD· 4 shared Claude Jourdan Le SauxiD· 3 shared Kiana GarakaniiD· 3 shared Michael A. MatthayiD· 3 shared Paul J. WoltersiD· 3 shared Tsung Che Ho· 3 shared Dean SheppardiD· 2 shared Marylène Toigo· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

Harold A. ChapmanORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 10, 2026

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).

Stefano A. Iantorno, Ying Wei, Kiana Garakani…·Claude Jourdan Le Saux

This study identifies age-related epigenetic changes in AT2 cells that promote basal cell metaplasia, contributing to idiopathic pulmonary fibrosis.

DOI 10.64898/2026.06.09.731212

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Cell BiologybioRxivPreprintDec 11, 2025

Alveolar Type II Cell-derived MMP1high basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.

Kiana Garakani, Alexis N. Brumwell, Marylène Toigo…·Harold A. Chapman

The paper identifies MMP1high basal cells derived from alveolar type II cells that contribute to microcyst formation in IPF, suggesting a therapeutic target through MMP inhibition or WNT modulation.

DOI 10.64898/2025.12.08.693033

humanspatial transcriptomics

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Cell BiologyJournal of Clinical InvestigationPeer-reviewedJul 9, 2024

A fibroblast-derived TGFβ/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

M. L. Cohen, Alexis N. Brumwell, Tsung Che Ho…·Claude Jourdan Le Saux

97 citationstop 1%

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Molecular BiologyPLoS ONEPeer-reviewedJan 9, 2019

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

Maike Thamsen, Rajarshi Ghosh, Vincent C. Auyeung…·Feroz R. Papa

This study shows that inhibiting IRE1α kinase/RNase reduces lung fibrosis in mice by blocking the terminal UPR, with two compounds demonstrating efficacy in preventing and reversing fibrosis.

65 citationstop 4%

mouseexperimental assay

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