Author

Jon L. Collins

University of North Carolina at Chapel HillORCID 0009-0007-8086-1802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C.H. ArrowsmithiD· 2 shared John R. Tabor· 2 shared Lindsey Ingerman JamesiD· 2 shared Nicholas Gene BrowniD· 2 shared Aamir Mehmood· 1 shared Adam FunkiD· 1 shared Ailing Pon· 1 shared Andrew W. StamfordiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

C.H. ArrowsmithORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 23, 2026

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22

Kevin Robertson, Sascha Josef Amann, Tongkun Liu…·Nicholas Gene Brown

This paper reveals the structural basis of NSD2 degradation via SCF-FBXO22 recruitment, showing how aldehyde-based degraders induce conformational changes for covalent binding and efficient protein degradation.

2 citations

experimental assayprotein folding & dynamics

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BiochemistryNature Chemical BiologyPeer-reviewedJul 4, 2024

Recruitment of FBXO22 for Targeted Degradation of NSD2

Yan Nie, John R. Tabor, Jianping Li…·C.H. Arrowsmith

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

73 citationstop 1%

humanexperimental assay

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