Michael A. Gildea

This study shows that peripheral ischemia accelerates hematopoietic aging, promoting tumor growth by skewing immune cell composition and enhancing immunosuppression.

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

The paper measures in vivo rates of the first and second chemical steps of pre-mRNA splicing across the genome and identifies splice site sequences and ribosomal protein gene features as key determinants of splicing rates.

The paper introduces a targeted RNA-sequencing method using complex primer pools to detect rare splice isoforms with high precision.