Léa Bardoulet

This study identifies CRY-NLRP3 complexes as a circadian checkpoint that modulates inflammasome activation and drug response, showing time-of-day effects on inflammation and drug efficacy.

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

This paper introduces an optogenetic method to control ASC oligomerization, enabling the study of inflammasome activation without PAMPs or DAMPs.