Author

Ruth Adafia

University of Massachusetts AmherstORCID 0009-0008-4634-6273Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Margaret M. StrattoniD· 2 shared Alfred Samkutty· 1 shared Ana P. Torres‐OcampoiD· 1 shared Anne Sofie G. LarseniD· 1 shared Annette E. LangkildeiD· 1 shared Bente FrølundiD· 1 shared Can ÖzdeniD· 1 shared Christine L. GeeiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

Margaret M. StrattonORCID

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2 papers

Recent·Most cited

BiophysicsProtein SciencePeer-reviewedSep 14, 2024

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

Dilip Narayanan, Anne Sofie G. Larsen, Stine Juul Gauger…·Sara M. Ø. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

5 citations

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistryProtein SciencePeer-reviewedMar 19, 2024

CaMKIIalpha and CaMKIIbeta hub domains adopt distinct oligomeric states and stabilities

Can Özden, Sara MacManus, Ruth Adafia…·Margaret M. Stratton

This study investigates the oligomeric states and stability of CaMKIIalpha and CaMKIIbeta hub domains, revealing differences in their stoichiometry and stability in solution.

4 citations

experimental assay

𝕏 PostBluesky