Haziq K. Moinudeen

The paper shows how functional redundancy among enzymes can lead to specialization without loss of vital reaction support, even without direct fitness rewards for narrow profiles.

TCF25 is mostly cytoplasmic with a perinuclear membrane-proximal pool, stabilises GPRASP2 against proteasomal degradation, and its C-terminal residues 604-664 are required for their association.

The paper introduces a geometric framework to analyze protein sequence space coverage and connects it to heuristic discovery times using a stochastic exploration model.