Author

Jeffrey B. Klarenbeek

The Netherlands Cancer InstituteORCID 0009-0009-2825-4727Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Assay:fluorescence / live-cell microscopy· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Kees JalinkiD· 3 shared Bram van den BroekiD· 2 shared Giulia ZanettiiD· 2 shared Sravasti MukherjeeiD· 2 shared Cor LieftinkiD· 1 shared Dimitris SfakianakisiD· 1 shared Dominique Kemps· 1 shared Farid El OualidiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

Kees JalinkORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 11, 2025

Beyond Static Screens: optical pooled screening of signaling dynamics using time-lapse FLIM

Sravasti Mukherjee, Menno van Tooren, Dimitris Sfakianakis…·Kees Jalink

The paper develops a high-throughput live-cell screening platform using time-lapse FRET-FLIM to study dynamic signaling phenotypes, demonstrating its effectiveness in identifying regulators of cAMP signaling.

DOI 10.1101/2025.07.11.664338

humanfluorescence / live-cell microscopy

𝕏 PostBluesky

Cell BiologyFEBS LettersPeer-reviewedDec 31, 2024

Cytosolic Enhanced Dark Epac-Based FRET Sensors for Intracellular cAMP detection in live cells via FLIM

Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink

The paper presents and characterizes mutations that improve cytosolic localization in FLIM-based cAMP FRET sensors while maintaining performance.

5 citations

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky

Cell BiologyiSciencePeer-reviewedJun 13, 2024

Radical differences between two FLIM microscopes affect interpretation of cell signaling dynamics

Sravasti Mukherjee, Jeffrey B. Klarenbeek, Farid El Oualid…·Kees Jalink

This study compares two FLIM microscopes and finds that differences in cAMP kinetics are due to phototoxicity from FluoroBrite medium, not the imaging technique itself.

5 citations

humanfluorescence / live-cell microscopy

𝕏 PostBluesky