Author

Macy L. Lozen

The University of Texas Southwestern Medical CenterORCID 0009-0009-6267-8152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Ailong KeiD· 1 shared Aydé Mendoza‐OlivaiD· 1 shared Binh An NguyeniD· 1 shared Chunyi HuiD· 1 shared Harichandra D. TagadiD· 1 shared Jaime Vaquer‐AliceaiD· 1 shared Katerina KonstantouleaiD· 1 shared Ki Hyun NamiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Ailong KeORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 8, 2026

An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism

Laxmikant G. Gadhe, Binh An Nguyen, María del Carmen Fernández‐Ramírez…·Nikolaos N. Louros

This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.

DOI 10.64898/2026.09.04.749224

humanexperimental assay

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BiochemistryMolecular CellPeer-reviewedJan 21, 2024

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications

Chunyi Hu, Mason T. Myers, Xufei Zhou…·Ailong Ke

This study defines the DNA binding and cleavage mechanisms of Type I-C CRISPR-Cas3 using cryo-EM and identifies anti-CRISPR proteins that inhibit its activity in human cells.

27 citations

humanstructural biology

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