Marije Havermans

This study shows MECOM represses myeloid differentiation by inhibiting CEBPA, and its overexpression in AML reduces CEBPA levels, maintaining stem cell state.

This study identifies EVI1's interaction with CTBP1/CTBP2 as critical for AML and shows that inhibiting this interaction can block leukemic growth.

This study shows that Gata2 regulates Gfi1b to control endothelial-to-hematopoietic transition and HSPC maturation, with reduced Gata2 leading to impaired hematopoietic programming.