Michael Worcester

This study shows PIP4K inhibits PIP5K lipid kinase activity by disrupting its membrane-mediated dimerization, maintaining PI(4,5)P2 homeostasis.

The paper demonstrates that human p38 MAPK selects targets through frequency-dependent biochemical resonance, using oscillating activation states to encode stimuli and activate specific genetic responses.

The paper shows that single-molecule lipid biosensors reduce inhibition of endogenous effector proteins and improve kinetic fidelity in PI3K signaling studies.

This paper describes a low-cost DIY stage-top incubation device for human cell imaging using 3D printing and SBCs, reducing costs by 100x compared to commercial alternatives.

This study develops a method to express, purify, and insert SARS-CoV-2 M protein into lipid bilayers, characterizing its structural properties using AFM and Cryo-EM.