Killing the enemy or making it your ally? The effects of thiostrepton on tumor associated macrophages
D. A. Pereira-Martins, J. Hilberink, I. Weinhauser, E. Rego, G. Huls, J. J. Schuringa
Abstract
Attempts to convert a tumor supportive M2-polarized macrophage microenvironment into a tumor suppressive M1-polarized one have recently received considerable attention. However, the specificity of novel compounds, their mode-of-action, and efficacy on presumed target cells in vivo needs to be interpreted with caution.
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