The CALERIE™ Genomic Data Resource

Calen Patrick Ryan; David L. Corcoran; Nirad Banskota; Claire Eckstein Indik; Aris Floratos; Richard A. Friedman; Michael Steffen Kobor; Virginia B. Kraus; William E. Kraus; Julia L. MacIsaac; Melissa C. Orenduff; Carl F. Pieper; James P. White; Luigi Ferrucci; Steve Horvath; Kim M. Huffman; Daniel W. Belsky

doi:10.1038/s43587-024-00775-0

GenomicsNature AgingDec 13, 2024

Peer-reviewed journal article

The CALERIE™ Genomic Data Resource

Calen Patrick Ryan iD, David L. Corcoran iD, Nirad Banskota iD, Claire Eckstein Indik iD, Aris Floratos iD, Richard A. Friedman iD, Michael Steffen Kobor iD, Virginia B. Kraus iD, William E. Kraus iD, Julia L. MacIsaac iD, Melissa C. Orenduff iD, Carl F. Pieper iD, James P. White iD, Luigi Ferrucci iD, Steve Horvath iD, Kim M. Huffman iD, Daniel W. Belsky iD

Abstract

Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from CALERIE-2 - the first ever randomized, controlled trial of long-term CR in healthy, non-obese humans - broadly supports a similar pattern of effects in humans. To expand our understanding of the molecular pathways and biological processes underpinning CR effects in humans, we generated a series of genomic datasets from stored biospecimens collected from n=218 participants during the trial. These data constitute the first publicly-accessible genomic data resource for a randomized controlled trial of an intervention targeting the biology of aging. Datasets include whole-genome SNP genotypes, and three-timepoint-longitudinal DNA methylation, mRNA, and small RNA datasets generated from blood, skeletal muscle, and adipose tissue samples (total sample n=2327). The CALERIE Genomic Data Resource described in this article is available from the Aging Research Biobank. This multi-tissue, multi-omic, longitudinal data resource has great potential to advance translational geroscience.

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