Ag+-regulated aptamers to thrombin
Rugiya Alieva, Svetlana V. SokolovaiD, Ilya Oleynikov, Роман А. НовиковiD, Timofei S. ZatsepiniD, Andrey V. AraloviD, Elena G. ZavyalovaiD
Abstract
Nucleic acid aptamers are artificial recognition elements with high potential in biotechnology. Approaches for aptamer affinity optimization and activity regulation are required for aptamer-based nanodevices. Here thrombin aptamer affinity was increased by a single nucleotide modification with 7,8-dihydro-8-oxo-1,N6-ethenoadenine. Whereas a double modification makes the aptamer activity Ag+-dependent.
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