Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection

Hemant Suryawanshi; Pavel S Morozov; Thangamani Muthukumar; Benjamin Robert tenOever; Masashi Yamaji; Zev Williams; Thomas Tuschl

doi:10.1101/2020.04.11.034603

BioinformaticsbioRxivApr 11, 2020

Preprint

Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection

Hemant Suryawanshi iD, Pavel S Morozov iD, Thangamani Muthukumar iD, Benjamin Robert tenOever iD, Masashi Yamaji iD, Zev Williams iD, Thomas Tuschl iD

Abstract

We have analyzed the cell-type-specific expression of the renin-angiotensin system (RAS) components across 141 cell types or subtypes as defined by single-cell RNA-seq (scRNA-seq) analysis. ACE2, one of the components of RAS, also facilitates SARS-CoV-2 entry into cells in cooperation with its associated protease TMPRSS2. Therefore, our analysis also contributes to the understanding of SARS-CoV-2 infection, spreading of the virus throughout the body, and potential viral interference with RAS in COVID-19 patients.

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