Thomas Tuschl

This study defines the single-cell landscape of Class II lupus nephritis and identifies fibroblast transcriptional programs and chronicity index as potential predictors of kidney outcomes.

This study identifies ZC3H7A and ZC3H7B as RNA-binding proteins that regulate mRNA stability and translation by targeting non-optimal A/U3 codons.

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

This study uses scRNA-seq to analyze kidney allograft biopsies and identifies recipient-derived fibroblasts and other cell states associated with fibrosis and rejection.

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

This study shows that RTEL1 helicase regulates TERRA RNA abundance and localization, with implications for telomere stability and disease.

The paper examines cell-type-specific expression of RAS components across 141 cell types using scRNA-seq and links ACE2 expression to SARS-CoV-2 infection mechanisms.

This study improves detection of extracellular mRNAs using modified small RNA-sequencing, revealing their potential as biomarkers and showing increased resolution in disease states.

The paper analyzes RBP-RNA interactions across 64 RBPs to identify regulatory modules and their functional roles in RNA metabolism and localization.