bioRxivPathologyPreprint
Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques
Z.-M. Ma, K. J. Olstad, K. K. A. Van Rompay, S. S. Iyer, C. J. Miller, J. R. Reader
Abstract
Pulmonary immunity against SARS-CoV-2 infection has not been well studied. This study investigated the distribution of immune cells int the lungs of 8 rhesus macaques experimentally infected with SARS-CoV-2, and euthanized 11-14 days later. Using immunohistochemistry, inducible bronchus-associated lymphoid tissue was found in all animals. The inducible bronchus-associated lymphoid tissues were composed of B cells, T cells, and follicular dendritic cells with evidence of lymphocyte priming and differentiation. This suggests local immunity plays an important role in the SARS-CoV-2 infection. Further study of local immunity in the lung would benefit our understanding of SARS-CoV-2 pathogenesis and could lead to new interventions to control the SARS-CoV-2 infection and disease.
- organism: rat
- assay: imaging
- research focus: host-pathogen & immune response
- approach: experimental assay
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues
C. E. Nelson, S. Namasivayam, … D. L. Barber·bioRxiv·Jan 6, 2022
- IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
C. E. Nelson, T. W. Foreman, … D. L. Barber·bioRxiv·Sep 13, 2022
- A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection
- Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure
R. Fischer, T. Bushmaker, … N. van Doremalen·bioRxiv·Sep 11, 2023
- Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques
H. Ishigaki, M. Nakayama, … Y. Itoh·bioRxiv·Aug 18, 2020
- Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
E. Mitsi, M. O. Diniz, … D. M. Ferreira·bioRxiv·Jan 25, 2023