R. Fischer

Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

CD4 T cell contact drives macrophage cell cycle progression and susceptibility to lentiviral transduction

The paper shows that CD4 T cell contact induces macrophage cell cycle progression from G0 to G1, increasing their susceptibility to lentiviral transduction.

Transmission dynamics of MERS-CoV in a transgenic human DPP4 mouse model

This study demonstrates limited MERS-CoV transmission via aerosol, fomite, and direct contact in a transgenic human DPP4 mouse model.

SCF cyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair

The paper identifies SCF cyclin F's role in regulating EXO1 degradation to control cell cycle-dependent DSB repair pathways.

Extracellular vesicles from patients with coronary artery disease (CAD) demonstrate enhanced pro-coagulatory activity.

This study finds that extracellular vesicles from CAD patients show increased pro-coagulatory activity despite similar numbers to controls, suggesting a role in CAD pathogenesis.

Compartmentalized SARS-CoV-2 replication in upper versus lower respiratory tract after intranasal inoculation or aerosol exposure

This study compares SARS-CoV-2 replication in rhesus macaques after intranasal inoculation or aerosol exposure, finding differences in respiratory tract involvement.

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

Environmental Persistence and Disinfection of Lassa Virus

This study examines the environmental persistence of Lassa virus strains on surfaces and their inactivation by sodium hypochlorite.

Stability of mpox (monkeypox) virus in bodily fluids and wastewater

This study investigates the stability of MPXV in bodily fluids and wastewater, finding it remains infectious in protein-rich fluids and is effectively neutralized by chlorination.

A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma syndrome negatively regulates telomere length

This study identifies FAM111B as a regulator of telomere length through interactions with the nuclear pore complex, independent of telomerase, and links its dysfunction to genomic instability in HFP patients.

Calredoxin regulates the chloroplast NADPH-dependent thioredoxin reductase in Chlamydomonas reinhardtii

The paper investigates the role of calredoxin (CRX) in regulating the chloroplast NADPH-dependent thioredoxin reductase (NTRC) in Chlamydomonas reinhardtii, showing that CRX controls redox balance and photosynthesis efficiency.

Comparative aerosol and surface stability of SARS-CoV-2 Variants of Concern

This study compares aerosol and surface stability of SARS-CoV-2 variants, finding early VOCs more stable than WA1, but Delta and Omicron do not show increased stability, suggesting stability changes are not the main driver of transmissibility.

Synchronization of oscillatory growth prepares fungal hyphae for fusion

This paper shows fungal hyphae use oscillatory signaling and calcium-dependent growth to prepare for cell fusion, transitioning from individual 'monologue' to coordinated 'dialogue' when interacting.

LARP1 regulates metabolism and mTORC1 activity in cancer

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

Deep topographic proteomics of a human brain tumour

This paper develops a workflow for spatially-resolved proteomics in human brain tumours, identifying spatial markers and immune-related protein networks in tissue slices.

UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

This study shows UV-C light prevents airborne SARS-CoV-2 transmission between hamsters.

Increased aerosol transmission for B.1.1.7 (alpha variant) over lineage A variant of SARS-CoV-2

This study shows that the B.1.1.7 variant of SARS-CoV-2 is more efficiently transmitted via aerosols than lineage A in Syrian hamsters.

Immunogenicity of low dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

This study evaluates the immunogenicity of a low-dose prime-boost mRNA vaccine in non-human primates, finding limited antibody and T cell responses in some animals.

Multiview super-resolution microscopy

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

Prior aerosol infection with lineage A SARS-CoV-2 variant protects hamsters from disease, but not reinfection with B.1.351 SARS-CoV-2 variant

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 1 disease

This study shows that the ChAdOx1 nCoV-19 vaccine protects Syrian hamsters from SARS-CoV-2 B.1.1.7 and B.1.351 variants, preventing weight loss, lung lesions, and viral replication.

Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018

The paper examines the environmental stability, replication kinetics, and pathogenicity of diverse MERS-CoV strains and SARS-CoV-2, finding variation in stability and pathogenicity among isolates.

CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

The paper shows that circadian rhythms persist in mice lacking CRY, suggesting that transcriptional feedback is not essential for timekeeping, but rather contributes to robustness.

From adverse to beneficial - contrasting dietary effects of freshwater mixotrophs on zooplankton

This study contrasts the dietary effects of freshwater mixotrophs on zooplankton, finding that species-specific toxicity and environmental factors influence survival outcomes.

Natural SARS-CoV-2 infections, including virus isolation, among serially tested cats and dogs in households with confirmed human COVID-19 cases in Texas, USA

The study investigates SARS-CoV-2 infections in cats and dogs from households with human COVID-19 cases, finding 47.1% of cats and 15.3% of dogs tested positive, with most asymptomatic and viral RNA persistence observed.