Logical modelling and analysis of cellular regulatory networks with GINsim 3.0

Aurélien Naldi; Céline Hernandez; Wassim Abou-Jaoudé; Pedro T. Monteiro; Claudine Chaouiya; Denis Thieffry

doi:10.3389/fphys.2018.00646

Systems BiologyFrontiers in PhysiologyJun 19, 2018

Peer-reviewed journal article

Logical modelling and analysis of cellular regulatory networks with GINsim 3.0

Aurélien Naldi iD, Céline Hernandez iD, Wassim Abou-Jaoudé iD, Pedro T. Monteiro iD, Claudine Chaouiya iD, Denis Thieffry iD

Abstract

The logical formalism is well adapted to model large cellular networks, for which detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step towards the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.

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