Alexander P. Clark

The paper identifies SP1 as a transcription factor necessary for human atrial cardiomyocyte identity, showing it interacts with NR2F2 to drive gene regulation.

This paper introduces CARBONITE, a method that links calcium dynamics with molecular markers in single cardiomyocytes, revealing functional and identity heterogeneity.

This study shows that reduced TBX5 dosage disrupts atrial cardiomyocyte identity, leading to cellular and molecular changes associated with atrial diseases.

This study identifies MEF2C-dependent gene regulatory networks in specific heart segments and shows their role in heart tube morphogenesis using multi-omics data and deep learning.

The paper introduces Netflux, a user-friendly tool for simulating biological networks without programming, and provides a tutorial on its use for modeling and perturbation analysis.

This paper develops a computational model to identify and correct artefacts in voltage-clamp experiments, improving the accuracy of ion channel recordings.