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FreeSurfer version-shuffling can boost brain age predictions

Max KorbmacheriD, Lars Tjelta WestlyeiD, Ivan I. MaximoviD

Abstract

Abstract / Key pointsO_LIThe influence of FreeSurfer version-dependent variability in reconstructed cortical features on brain age predictions is average small when varying training and test splits from the same data. C_LIO_LIFreeSurfer version differences can lead to some variability in brain age dependent on the choice of algorithm and individual differences in brain morphometry, highlighting the advantage of repeated random train-test splitting. C_LIO_LIShuffling of differently processed FreeSurfer data dependent on the FreeSurfer version increases performance and generalizability of the brain age prediction model. C_LI

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02 /Specification & Classification

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