H. Cui

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

Mutating the arginine residue within the FRNK motif of HC-Pro yield highly attenuated strains that confer complete cross protection against telosma mosaic virus (TelMV) in passion fruit (Passiflora edulis)

Virus-induced gene silencing (VIGS) as a tool for functional genetic analysis in passion fruit plants

This paper develops a VIGS vector in passion fruit to study gene function in biosynthesis of health-promoting compounds.

Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides

The paper identifies lipoavitides, a novel class of RiPP/fatty acid hybrid lipopeptides with a unique HMP modification, and describes their biosynthetic pathway.

An axonemal intron splicing program sustains Plasmodium male development

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.

A redundant chloroplast protein is co-opted by potyvirids as the scaffold protein to mediate viral intercellular movement complex assembly

This study identifies HCPro2 as a potyvirus-encoded scaffold protein that interacts with viral and host factors to assemble an intercellular movement complex, promoting viral infection.

Cotyledon Peeling Method for Passion Fruit Protoplasts: a versatile cell system for transient gene expression in passion fruit (Passiflora edulis)

This paper introduces a new method for isolating and transforming passion fruit protoplasts, achieving high yield and transfection efficiency for transient gene expression.

AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

Genome mining unveils a class of ribosomal peptides with two amino termini

The paper identifies a new class of ribosomal peptides, daptides, with two amino termini, discovered through genome mining and characterized experimentally.

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

Antibody avidity and multi-specificity combined to confer protection against SARS-CoV-2 and resilience against viral escape

This study develops a multimeric antibody platform (Multabody) that enhances neutralization potency and breadth against SARS-CoV-2 and its variants through avidity and multi-specificity.

The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

Inner membrane complex proteomics reveals a palmitoylation cascade regulating intraerythrocytic development of malaria parasite

The paper identifies IMC proteins in Plasmodium yoelii and shows DHHC2 palmitoylates CDPK1 and GAP45 for their localization, essential for schizont development.

SCARECROW maintains the stem cell niche in Arabidopsis root by ensuring telomere integrity

This study identifies SCARECROW's role in maintaining telomere integrity and genome stability in Arabidopsis root stem cells through regulation of TEN1 and related factors.

Coil-to-Helix Transition at the Nup358-BicD2 Interface Activates BicD2 for Dynein Recruitment

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission

This study identifies a malaria parasite phospholipid flippase, ATP7, as essential for ookinete survival in mosquito midgut epithelium, revealing its role in membrane asymmetry maintenance and transmission.

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

Impact of Prior Infection on Protection and Transmission of SARS-CoV-2 in Golden Hamsters

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

NbCycB2 represses Nbwo activity via a negative feedback loop in the tobacco trichome development

Coiled-coil registry shifts in the F684I mutant of Bicaudal result in cargo-independent activation of dynein motility

The paper shows that a coiled-coil registry shift in the F684I mutant of BicD activates dynein motility without cargo, and suggests this mechanism may modulate cargo selection in BicD2.

The Meta-Position of Phe4 in Leu-enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors

The paper investigates how substituting the meta-position of Phe4 in Leu5-enkephalin affects its binding affinity, signaling bias, and stability at delta and mu opioid receptors.

SPOP Promotes Ubiquitination and Degradation of MyD88 to Suppress the Innate Immune Response

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

A mechanism coordinating root elongation, endodermal differentiation, redox homeostasis and response

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein recruitment upon cargo-binding

This paper investigates how coiled-coil registry shifts in BicD2 activate dynein recruitment upon cargo-binding, linking structural changes to disease mechanisms.

Lipid interactions enhance activation and potentiation of cystic fibrosis transmembrane conductance regulator (CFTR)

This study shows that lipid interactions are crucial for CFTR channel activation and potentiation, as demonstrated by higher catalytic activity and response to ivacaftor when CFTR is purified with associated lipids.