MSI.EAGLE: An Open-Source GUI for Streamlined Mass Spectrometry Imaging Analysis
Daniel James BoehmleriD, Ashley G. WoolforkiD, Ai Wen TaniD, Arjun SenguptaiD, Pinky KainiD, Om B PateliD, Farheen AkhtariD, George McClungiD, Daniel AckermaniD, Terence P.F. GadeiD, Garret A. FitzGeraldiD, Aalim M. WeljieiD
Abstract
Mass Spectrometry Imaging (MSI) is an emergent tool for analyzing spatial molecular distributions, yet data complexity often hinders effective analysis. MSI.EAGLE, an open-source R-Shiny application, makes analysis accessible for non-specialists by integrating advanced tools in a user-friendly interface. The workflow leverages tools from the Cardinal MSI package, with enhanced phenotyping, segmentation, statistical analysis and visualization. The application addresses a gap in spatial biology research by empowering a broader scientific community.
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