Dynamics of SARS-CoV-2 genetic mutations and their information entropy
Abstract
We report an investigation of the mutations dynamics of the SARS-CoV-2 virus using Shannons information theory. Our study includes seventeen RNA genetic sequences collected at different geographic locations and timeframes ranging from Dec. 2019 to Oct. 2021. The data shows a previously unobserved relationship between the information entropy of genomes and their mutation dynamics. The information entropy of the mutated variants decreases linearly with the number of genetic mutations with a negative slope of 1.52 x 10-5 bits / mutations, pointing to a possible deterministic approach to the dynamics of genetic mutations. The method proposed here could be used to develop a predictive algorithm of genetic mutations.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 1
- Organism
- Assay
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- A new method to study genome mutations using the information entropy
Melvin M. Vopson, Samuel C. Robson·Physica A Statistical Mechanics and its ApplicationsPeer-reviewed·Aug 31, 2021
- Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning.
Md. Shahadat Hossain, A. Q. M. Sala Uddin Pathan, … Md. Mizanur Rahaman·Informatics in Medicine UnlockedPeer-reviewed·Jan 1, 2021
- SARS-CoV-2's evolutionary capacity is mostly driven by host antiviral molecules
Kieran D. Lamb, Martha M. Luka, … David L. Robertson·bioRxiv·Apr 7, 2023
- Time series analysis of SARS-CoV-2 genomes and correlations among highly prevalent mutations
Neha Periwal, Shravan B. Rathod, … Vikas Sood·Microbiology SpectrumPeer-reviewed·Sep 7, 2022
- Worldwide tracing of mutations and the evolutionary dynamics of SARS-CoV-2
Z.-Y. Zhou, H. Liu, … Y.-P. Zhang·bioRxiv·Aug 7, 2020
- Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution
M. Amicone, V. Borges, … I. Gordo·bioRxiv·May 19, 2021