Altered brain-wide auditory networks in fmr1-mutant larval zebrafish

Lena Constantin; Rebecca Elizabeth Poulsen; Itia A. Favre‐Bulle; Michael A. Taylor; Biao Sun; Geoffrey J. Goodhill; Gilles Claude Vanwalleghem; Ethan K. Scott

doi:10.1101/722082

NeurosciencebioRxivAug 5, 2019

Preprint

Altered brain-wide auditory networks in fmr1-mutant larval zebrafish

Lena Constantin iD, Rebecca Elizabeth Poulsen iD, Itia A. Favre‐Bulle iD, Michael A. Taylor iD, Biao Sun iD, Geoffrey J. Goodhill iD, Gilles Claude Vanwalleghem iD, Ethan K. Scott iD

Abstract

Altered sensory processing is characteristic of several psychiatric conditions, including autism and fragile X syndrome (FXS). Here, we use whole-brain calcium imaging at cellular resolution to map sensory processing in wild type larval zebrafish and mutants for fmr1, which causes FXS in humans. Using functional analyses and graph theory, we describe increased transmission and reduced filtering of auditory information, resulting in network-wide hypersensitivity analogous to the auditory phenotypes seen in FXS.

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