Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
Udaysankar ChockanathaniD, Emily J. Warner, Loel C. Turpin, M. Kerry O’BanioniD, Krishnan PadmanabhaniD
Abstract
While the link between amyloid {beta} (A{beta}) accumulation and synaptic degradation in Alzheimers disease (AD) is known, the consequences of this pathology on coding remain unknown. We found that the entropy across neural ensembles was lower in the CA1 region in the APP/PS1 mouse model of A{beta}, thereby reducing the populations coding capacity. Our results reveal a network level signature of the deficits A{beta} accumulation causes to the computations performed by neural circuits.
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